We used a proteomics analysis to confirm that cells expressed endogenous Gal-3, and found that addition of competitive oligosaccharide ligands for the lectin altered the lateral mobility of the integrin.. PLoS ONE 12(10): e0184378 Editor: Ivan R Nabi, University of British Columbia, CANADA Received: June 13, 2017; Accepted: August 22, 2017; Published: October 10, 2017 Copyright: © 2017 Yang et al.
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Citation: Yang EH, Rode J, Howlader MA, Eckermann M, Santos JT, Hernandez Armada D, et al.. (2017) Galectin-3 alters the lateral mobility and clustering of β1-integrin receptors.. Data Availability: All relevant data are within the paper and its Supporting Information files. Visio For Mac Download
Fluorescence microscopy allowed us to confirm that exogenous Gal-3 resulted in reorganization of the integrin into larger clusters.. It was easy to seize peaceful planets and destroy races refused to obey a new human order until humans faced the one that didn’t rely on the development of their technology.. Treatment of cells with Gal-3 increased β1-integrin mediated migration with no apparent changes in viability. How To Build App File For Mac Not To Reference Java 6
Specific glycan structures may interact with endogenous lectins that enforce or disrupt receptor-receptor interactions.. In this study, we have examined the interaction of Galectin-3 (Gal-3), a human lectin, with adhesion receptors.. People of future are afraid that their greatest enemy will be an alien race with telepathy and other mental abilities.. Glycoproteins bound by multivalent lectins may form extended oligomers or lattices, altering the lateral mobility of the receptor and influencing its function through endocytosis or changes in activation.. We measured the effect of recombinant Gal-3 added exogenously on the lateral mobility of the α5β1 integrin on HeLa cells. 5842b3f4e3 Unduh Chrome Untuk Bb Excel Example